HOW NARCAN WORKS
Reversing an Opioid Overdose
Naloxone is used to reverse an opioid overdose. It can be administered either by intramuscular injection or as a nasal spray. It works by blocking the opioid receptor sites, thus reversing the toxic effect of the opioid.
Naloxone (Narcan) Displaces opioids at the Mu Opioid Receptor, Reversing the Effects of Opioid Overdose.
As shown in the diagram, if naloxone is introduced to an opioid-bound receptor, it will kick the opioid out of the receptor because it has a higher affinity for the receptor. It does not stimulate the receptor because it does not sit in the activation zone, therefore, it is considered to be an opioid antagonist.
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